TO ENHANCE JOINT AND TENDON 

THERAPEUTICS ON CANINES.

 
 

 PHYSICAL AND CHEMICAL PROPERTIES 

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 BIOTHERAPEUTIC  PROPERTIES
LACRILON, is a natural Biopolymer (molecular weight 35.000-45.000 Daltons)ultrapurified by original procedure which assures its stability (can be kept for 2 years at room temperature) and together with the suitable balance of its sulphated groups, it maximizes its biotherapeutic action. The Sulphated Glycosaminoglycans (Sulphate "A" Condroitin and Sulphate "B" Condroitin and Keratan sulphate) are the main extra-cellular components(matrix) of the Joint and Cartilage with wide biological activity. 

BIOAVAILABILITY

CARTIAGE REPAIRING  

"With no intermediate steps"           LACRILON, is slowly released from the moment it is injected, having positive (+) tropism towards the fibrocartilagenous tissue, it lies selectively on the joint cartilage, where significant concentration (2-7 ug/g of tissue) will be spotted from the first day to 4 - 8 days after injection, contributing to the Matrix glycosaminoglycan pool and directly exerting its pharmacological therapeutic action.

LACRILON reaches the cartilage Directly and Stimulates  Biosynthesis; it induces of the condrocite to matrix formation and favours the formation of higher molecular weight Proteoglycan compounds(more efficients) restoring the damaged cartilage.

HISTOLOGICAL VIEW OF THE ARTICULAR CARTILAGE TINTION O-SAFRANINA (X250)         

1)Osteoarthritic cartilage not treated; erosion, cellular "nets" and tintion loss can be observed.

2)Osteoarthritic cartilage, after treatment with Sulphated Glycosaminoglycans; evident recovery of the structure can be observed, as well as tintion preservation with O-Safranine. 

CARTILAGE PROTECTION

 TENDONS  OSTEOGENESIS 
"Its delays catabolic processes" through : Lytic Enzyme blockade of the joint cartilage (colleagenases, ellastases, protoglycanases, metaloproteases, etc.). LACRILON favours collagenogenesis, mainly type II fibres(larger) which together with the effects mentioned above, improves and hastens the damaged tissue recovery. (Fractures)    LACRILON reduces the osteolitic process, it increases calcium total pool, its enteral absortion and bone deposits.
ANTIOXIDANT : It prevents lipid peroxidation, stabilizing the cellular membranes.
ANTIINFLAMMATORY - ANALGESIC : It blocks autocoids  (cellular mediators of inflammation).

                                                NATIONAL AND INTERNATIONAL TRIALS          

                                SUPPORT ITS THERAPEUTICS RESULT  

 

                  TO PREVENT HIP DYSPLASIA          

 

                  "Data  show that the early treatment with      

                      Sulphated Glycosaminoglycans on risky puppies  

                            reduce signs of hip dysplasia".                                      

 JOINT PATHOLOGIES

                              LACRILON IT ACTS DIRECTLY WITH NO

                             INTERMEDIATE STEPS.

                                  - It reaches the cartilage directly and stimulates matrix  

                                    components synthesis and aggregation (CARTILAGE REPAIRING).

                               - It delays catabolic processes (CARTILAGE PROTECTION). 

                             - It exerts antinflammatory and analgesic effects.

                           - It restores synovial liquid balance (Joint Homeostasis).
Box Containing: Dosing and Administration
 8 ml.Bottle 2-5 mg./Kg live weight- Hypodermic or Intramuscular.
Formula: Equivalent to 0,5-1 ml./animal. The practical dose
Each ml. contains: 120 mg Sulphated Glycosaminoglycan, may be 1 ml (regardless the animal weight as it has not
40 ml. Cl Na, 1 ml. Distilled water. side effects)
Prescription: Frequency: every 4-7 days; 8 shots or more 
Joint and Tendon Pathology Treatment: Arthritis, Arthrosis, according to the professional criteria.
Osteoarthrosis, Joint Cartilage Degenerative Contraindications-Precaution-Warming 
Processes-Osteocondrosis, Synovitis, Tendinitis, Hip No side effects at recommended doses.
Dysplasia Treatment and Prevention, Coadyuvant on Inject under strict aseptic conditions. 
Fracture repairing. Do not employ on animals hypersensitive to Sulfate 
Glycosaminoglycans.

 

Av. Santa Fe 2618 (1425)  Telephone(011) 4826-5832/5895       Buenos Aires - ARGENTINA